TY - JOUR
T1 - White-matter microstructure and hearing acuity in older adults
T2 - a population-based cross-sectional DTI study
AU - Rigters, Stephanie C.
AU - Cremers, Lotte G M
AU - Ikram, M. Arfan
AU - van der Schroeff, Marc P.
AU - De Groot, Marius
AU - Roshchupkin, Gennady V.
AU - Niessen, Wiro J.N.
AU - Baatenburg de Jong, Robert J.
AU - Goedegebure, André
AU - Vernooij, Meike W.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - To study the relation between the microstructure of white matter in the brain and hearing function in older adults we carried out a population-based, cross-sectional study. In 2562 participants of the Rotterdam Study, we conducted diffusion tensor imaging to determine the microstructure of the white-matter tracts. We performed pure-tone audiogram and digit-in-noise tests to quantify hearing acuity. Poorer white-matter microstructure, especially in the association tracts, was related to poorer hearing acuity. After differentiating the separate white-matter tracts in the left and right hemisphere, poorer white-matter microstructure in the right superior longitudinal fasciculus and the right uncinate fasciculus remained significantly associated with worse hearing. These associations did not significantly differ between middle-aged (51–69 years old) and older (70–100 years old) participants. Progressing age was thus not found to be an effect modifier. In a voxel-based analysis no voxels in the white matter were significantly associated with hearing impairment.
AB - To study the relation between the microstructure of white matter in the brain and hearing function in older adults we carried out a population-based, cross-sectional study. In 2562 participants of the Rotterdam Study, we conducted diffusion tensor imaging to determine the microstructure of the white-matter tracts. We performed pure-tone audiogram and digit-in-noise tests to quantify hearing acuity. Poorer white-matter microstructure, especially in the association tracts, was related to poorer hearing acuity. After differentiating the separate white-matter tracts in the left and right hemisphere, poorer white-matter microstructure in the right superior longitudinal fasciculus and the right uncinate fasciculus remained significantly associated with worse hearing. These associations did not significantly differ between middle-aged (51–69 years old) and older (70–100 years old) participants. Progressing age was thus not found to be an effect modifier. In a voxel-based analysis no voxels in the white matter were significantly associated with hearing impairment.
KW - Age-related hearing impairment
KW - DTI
KW - Hearing acuity
KW - Pure-tone audiogram
KW - Superior longitudinal fasciculus
KW - Uncinate fasciculus
KW - Voxel-based analysis
KW - White-matter tract
UR - http://www.scopus.com/inward/record.url?scp=85032859257&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2017.09.018
DO - 10.1016/j.neurobiolaging.2017.09.018
M3 - Article
AN - SCOPUS:85032859257
SN - 0197-4580
VL - 61
SP - 124
EP - 131
JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
ER -